We are engineering the global operating system for immune resilience. While fundamental discovery is accelerating, the path to clinical translation remains complex. We unify discovery, long-horizon capital, and clinical strategy to create a scalable clinical reality for the aging immune system.
We operate as the neutral global hub for the ecosystem. We transform fragmentation into alignment, establishing the consensus protocols, shared metrics, and data standards required to define, measure, and validate immune aging.
We have operationalized this vision through our first engine, the Burstcast. Designed to bridge disciplines and accelerate dissemination, it brings the global expert community closer to the science. This active network establishes the foundation for our long-term goal: building harmonized immune data assets and validated resilience metrics.
Late-life health loss often attributed to aging is not our inevitable fate. We believe that by elucidating the fundamental mechanisms of immune aging, we can translate that biology into actionable interventions and engineer a future of healthy longevity.
To achieve this, we believe in a community-driven approach. Finding the right collaborator (whether a cross-disciplinary researcher, a funder, or an industry partner) is like finding a substrate for an enzyme.
We aim to facilitate collaborative science and data sharing to help each other overcome bottlenecks in scientific work and bring fundamental science and industry work together.
The Immune-Aging Project is led by an executive team building the global infrastructure for immune resilience research.
Co-Founder & Executive Director
A systems biologist unraveling the networks of immune aging. His research at the Weizmann Institute of Science uncovered the heterogeneity of senescent cells and the specific mechanisms they use to evade immune clearance in aged tissues.
Co-Founder & Director of Scientific Engagement
An immuno-oncologist at INSERM bridging the gap between cancer biology and aging. Her research at the Weizmann Institute of Science demonstrated that senescent cells hijack the PD-L1 checkpoint to evade clearance, establishing a direct therapeutic link between cancer immunotherapy and longevity science.
Science is an expedition. The Burstcast moves beyond the static presentation to offer a live, evidence-based dialogue. We invite you to witness the "act of finding" as we navigate the data behind the findings, transforming a one-way broadcast into a shared discovery.
We contextualize the inquiry. We begin by bridging the gap between cellular mechanisms and human health, framing the narrative to answer the critical question: "Why does this specific problem matter?"
We define the contribution. The dialogue centers on one distinct, measurable claim: specifying exactly what is new and how this finding resolves a specific gap in our understanding of science.
We explore the key figures live, deconstructing the analytical approach to reveal the evidence and rigor that support the claim.
We open the floor to the ecosystem. A dedicated space for critical dialogue and diverse perspectives, exploring how these findings translate from the laboratory to the real world.
Exploring how the senescent peripheral immune system drives systemic age-associated organ damage.
Matt Youssefzadeh, Ph.D.
Asst. Professor, Columbia University
Defining T cell exhaustion and the stem-like subsets that sustain immunity in cancer and chronic infection.
Rafi Ahmed, Ph.D.
Professor, Emory University
Developing mTOR inhibitors to enhance the function of the aging immune system and improve vaccine response.
Joan Mannick, M.D.
CMO, Altos Labs
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